Hugh Kane preaches about the importance of returning to first principles and separating from unscriptural practices in the church. He emphasizes the need to question denominational names, the purpose of gathering, God's order of worship, the one-man ministry concept, the use of titles like 'Reverend,' the method of financing the Lord's work, and the growing apostasy in Christendom. Kane urges believers to come out from false teachings and practices, aligning themselves with God's truth and honoring His name above all else.