In this sermon, the preacher emphasizes the importance of simplifying life by focusing on one basic decision. He uses the story of Mary and Martha in Luke chapter 10 to illustrate this point. The preacher suggests that the challenges and distractions of modern society can lead to fragmentation, but by having a single-hearted desire for God, we can overcome these challenges. He also highlights the promise in Psalm 32:8 that God will guide us with His eye if we seek Him wholeheartedly.