Chuck Smith explores the theme of worth in his sermon 'What Are You Worth?' by emphasizing the vastness of God compared to human insignificance, as illustrated in Job's experience. He highlights that despite our attempts to elevate our self-worth through pride or material possessions, we ultimately face situations that reveal our limitations and smallness. Smith poses the critical question of what a man can give in exchange for his soul, underscoring that true redemption cannot be achieved through human efforts but only through the sacrifice of Jesus Christ. He concludes with the profound truth of God's love, which offers redemption to those who accept it, contrasting it with the dire consequences of rejection.