David Wilkerson emphasizes that when fear overwhelms us, we must focus on the greatness of God and recall His past deliverances. He illustrates this through Nehemiah, who encouraged the people of Jerusalem to remember God's might amidst their fears, and Moses, who reminded the Israelites of God's faithfulness against powerful enemies. By keeping a vision of God's majesty, believers can resist the grip of fear and find strength in His promises. The sermon calls for a remembrance of God's past actions to bolster faith in present trials.