David Wilkerson emphasizes the importance of focusing on God's greatness, using the awe-inspiring experience of astronaut Charlie Duke as a metaphor for recognizing the Creator's power. He reflects on God's dialogue with Job, where God reveals His sovereignty over creation, urging Job to shift his perspective from his suffering to the majesty of God. Wilkerson highlights that by keeping our eyes on God's greatness, we can overcome fear and doubt that often cloud our hearts. Ultimately, the sermon encourages believers to trust in God's omnipotence and care for His creation.