C.H. Spurgeon emphasizes that true comfort for Christians cannot be found in worldly pleasures, which he refers to as vanity. He acknowledges that while ungodly individuals may seek happiness in earthly delights, Christians are called to seek joy in a higher, spiritual realm. Spurgeon illustrates this with the story of a godly wife who, recognizing her husband's spiritual state, strives to make his earthly life as pleasant as possible. He warns that indulging in vain amusements can lead to spiritual starvation and vulnerability to temptation. The sermon concludes with a heartfelt plea for divine assistance to turn away from vanity and lies.