Chuck Smith emphasizes the certainty of God's Word, asserting that what God has spoken will undoubtedly come to pass. He highlights God's attributes of being all-knowing, absolute truth, and eternal, which necessitates our attention to His declarations. The sermon discusses the prophecy concerning Tyre, detailing how Nebuchadnezzar will conquer the city and its eventual desolation, serving as a reminder of the importance of heeding God's messages. Smith concludes by urging listeners to recognize the weight of God's words and the consequences of ignoring them.