David Wilkerson emphasizes the importance of trusting in God at all times, encouraging believers to resign themselves to His care as an act of faith. He illustrates this concept through Jesus' ultimate example of resignation on the cross, where He committed His spirit into the Father's hands, symbolizing the trust we should have in God's power and mercy. Wilkerson reassures that God promises to take full responsibility for our needs and protect us from evil, urging us to find peace in our resignation to Him. He highlights that true freedom comes from trusting God completely, leading to a life free from fear and anxiety. Ultimately, our Shepherd knows how to care for us, and by resting in His keeping power, we can navigate life's challenges without fear.