David Wilkerson emphasizes the call to pursue the fullness of Christ's blessings as outlined by Paul in his letter to the Ephesians. He highlights that true fullness is not about material wealth but about having a clear conscience and an open relationship with God, allowing His blessings to flow freely in our lives. Wilkerson reflects on Paul's confidence in his walk with Christ, which stemmed from his commitment to live without hidden sin and to strive for spiritual maturity. The ultimate goal is to receive God's commendation, 'Well done,' as a testament to our faithfulness. This pursuit of fullness is a divine task that every believer is called to embrace.