J.R. Miller discusses Paul's first missionary journey, focusing on the miraculous healing of a lame man in Lystra, which stirred the crowd to mistakenly worship Paul and Barnabas as gods. Despite the initial excitement, the fickleness of the people quickly turned against the apostles, illustrating the dangers of superficial admiration and the need for true loyalty in friendship. Miller emphasizes that while the apostles performed miracles, they were merely messengers of the living God, urging the people to turn from worthless idols to the true source of life. He warns against accepting glory that belongs to God alone and highlights the importance of recognizing God's hand in everyday blessings. The sermon concludes with a call for steadfastness in faith and loyalty among believers, as exemplified by the disciples who stood by Paul after his stoning.