Mike Bickle emphasizes the significance of Jesus being the 'First and the Last' in Revelation, highlighting that this title encapsulates both His divine sovereignty and His human experience. He explains that understanding these titles equips believers to endure hardships and remain steadfast in their faith. Bickle stresses that Jesus' humanity allows Him to empathize with our struggles, and His resurrection assures us of eternal rewards for our faithfulness. The sermon calls for a deeper revelation of Jesus to transform our lives and align our hearts with His eternal purpose.