David Wilkerson warns about the spiritual complacency and moral decay within God's people, as illustrated by the prophet Jeremiah. He emphasizes that many have become indifferent to sin, hiding behind a false sense of peace while neglecting the warnings of God's watchmen. The sermon calls believers to heed God's Word and remain obedient, as genuine renewal will face opposition from Satan. Wilkerson urges listeners to allow the Holy Spirit to examine their hearts and to strive for a blameless walk with the Lord in these challenging times.