C.H. Spurgeon emphasizes that the Lord has always been mindful of us, providing, comforting, and guiding us through all circumstances. He reassures us that God's unchanging nature guarantees His continued mindfulness and blessings in our lives. Spurgeon encourages gratitude for the times we have distinctly felt God's care and reminds us that His blessings are vast and eternal. The sermon calls us to bless the Lord for His unwavering attention and love towards us.