John Gill emphasizes the importance of humility before God, urging believers to submit quietly to His will and endure afflictions without complaint. He explains that being under the mighty hand of God is both a position of safety and a pathway to exaltation, as God opposes the proud but lifts up the humble. Gill reassures that those who humble themselves will be exalted in God's perfect timing, whether in this life or at the return of Christ. He encourages mourning over sin and recognizing our unworthiness, which fosters a deeper reverence for God's majesty.