A.B. Simpson emphasizes that God chooses the foolish, weak, base, despised, and things that are not to accomplish His purposes, challenging the notion that human wisdom and strength are necessary for service. He illustrates how God has historically used humble instruments, like Moses' rod and Gideon's small army, to confound the mighty, and how the simplicity of faith can lead to profound results. Simpson encourages believers to embrace their weaknesses and lowly status, as these are often the very qualities that God uses to demonstrate His power and grace. He concludes by affirming that true strength comes from being nothing in ourselves and allowing Christ to live through us.