Mike Bickle emphasizes the significance of Ephesians 3:14-19, highlighting the need for believers to pray for strength in their inner man to experience the fullness of God's presence and love. He explains that this prayer is a pathway to understanding the vastness of God's love, which surpasses knowledge, and encourages believers to seek a deeper relationship with God through prayer, obedience, and the Holy Spirit. Bickle outlines a four-stage progression in the Christian experience, urging the congregation to pursue strength and intimacy with God to fully comprehend His love and purpose for their lives.