John Nelson Darby explores the profound question from Psalms 8, 'What is man, that thou art mindful of him?' He emphasizes the contrast between man's insignificance and God's grand design, revealing that through Christ, humanity is elevated to a position of glory and honor. Darby explains that while angels are powerful beings, they do not share in the redemptive grace that God extends to humanity through Jesus, who became a man to redeem and associate us with Himself. He highlights the importance of Christ's suffering and how it enables Him to sympathize with our weaknesses, ultimately leading us to glory as joint-heirs with Him. The sermon concludes with the assurance that Christ, as our High Priest, understands our trials and provides grace in our time of need.