John Gill expounds on 1 Peter 2:22, emphasizing that Christ, though appearing in the likeness of sinful flesh and bearing the sins of humanity, was without sin both in nature and action. He highlights that Jesus faced accusations and suffering without any deceit or wrongdoing, serving as a model for patience in the face of suffering. Gill argues that if Christ, who was entirely innocent, endured such trials, then sinful humanity should also strive to bear their own sufferings with patience and grace.